Characteristics of clinical trials in rare vs. common diseases: A register-based Latvian study.

ABSTRACT:

Background

Conducting clinical studies in small populations may be very challenging; therefore quality of clinical evidence may differ between rare and non-rare disease therapies.

Objective

This register-based study aims to evaluate the characteristics of clinical trials in rare diseases conducted in Latvia and compare them with clinical trials in more common conditions.

Methods

The EU Clinical Trials Register (clinicaltrialsregister.eu) was used to identify interventional clinical trials related to rare diseases (n = 51) and to compose a control group of clinical trials in non-rare diseases (n = 102) for further comparison of the trial characteristics.

Results

We found no significant difference in the use of overall survival as a primary endpoint in clinical t

SUBMITTER: Logviss K 

PROVIDER: S-EPMC5882124 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature