Abundance, diversity and domain architecture variability in prokaryotic DNA-binding transcription factors.

ABSTRACT: Gene regulation at the transcriptional level is a central process in all organisms, and DNA-binding transcription factors, known as TFs, play a fundamental role. This class of proteins usually binds at specific DNA sequences, activating or repressing gene expression. In general, TFs are composed of two domains: the DNA-binding domain (DBD) and an extra domain, which in this work we have named "companion domain" (CD). This latter could be involved in one or more functions such as ligand binding, protein-protein interactions or even with enzymatic activity. In contrast to DBDs, which have been widely characterized both experimentally and bioinformatically, information on the abundance, distribution, variability and possible role of the CDs is scarce. Here, we investigated these issues associ

SUBMITTER: Perez-Rueda E 

PROVIDER: S-EPMC5882156 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature