Premature ovarian aging in BRCA carriers: a prototype of systemic precocious aging?

ABSTRACT:

Purpose

Though former evidence implies a correlation of breast cancer susceptibility gene (BRCA) mutation with reduced ovarian reserve, the data is yet inconsistent. Our aim was to investigate biomarkers of ovarian aging in a cohort of young healthy carriers of the BRCA mutation. We hypothesized that the role played by BRCA genes in aging pathways is not exclusive to the ovary.

Experimental design

Healthy female BRCA carriers, 40 years or younger and healthy male BRCA carriers, 50 years or younger, were enrolled in the study. Serum anti-mullerian Hormone (AMH), fibroblast growth factor-23 (FGF-23), Klotho and IL-1 were measured by enzyme-linked immunosorbent assay (ELISA). Ovarian AMH and protein kinase B (AKT) mRNA from BRCA carrier

SUBMITTER: Ben-Aharon I 

PROVIDER: S-EPMC5882308 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature