Pre-diagnostic biomarkers of metabolic dysregulation and cancer mortality.

ABSTRACT:

Introduction

The obesogenic milieu is a pro-tumorigenic environment that promotes tumor initiation, angiogenesis and metastasis. In this prospective cohort, we examined the association between pre-diagnostic metabolic biomarkers, plasma adiponectin, resistin, leptin and lipoprotein (a), and the risk of cancer mortality.

Methods

Prospective data was obtained from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort of Blacks and Whites followed from 2003 through 2012 for cancer mortality. We determined the association between metabolism biomarkers (log-transformed and tertiles) and risk of cancer mortality using Cox Proportional Hazards models with robust sandwich estimators to calculate the 95% confidence intervals (CIs), and adjusted for baseline cov

SUBMITTER: Akinyemiju T 

PROVIDER: S-EPMC5882320 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature