Multi institutional quantitative phantom study of yttrium-90 PET in PET/MRI: the MR-QUEST study.

ABSTRACT: BACKGROUND:Yttrium-90 (90Y) radioembolization involves the intra-arterial delivery of radioactive microspheres to treat hepatic malignancies. Though this therapy involves careful pre-treatment planning and imaging, little is known about the precise location of the microspheres once they are administered. Recently, there has been growing interest post-radioembolization imaging using positron-emission tomography (PET) for quantitative dosimetry and identifying lesions that may benefit from additional salvage therapy. In this study, we aim to measure the inter-center variability of 90Y PET measurements as measured on PET/MRI in preparation for a multi-institutional prospective phase I/II clinical trial. Eight institutions participated in this study and followed a standardized phantom filling

SUBMITTER: Maughan NM 

PROVIDER: S-EPMC5882483 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature