The Dorsal Medial Habenula Minimally Impacts Circadian Regulation of Locomotor Activity and Sleep.

ABSTRACT: In nocturnal rodents, voluntary wheel-running activity (WRA) represents a self-reinforcing behavior. We have previously demonstrated that WRA is markedly reduced in mice with a region-specific deletion of the transcription factor Pou4f1 (Brn3a), which leads to an ablation of the dorsal medial habenula (dMHb). The decrease in WRA in these dMHb-lesioned (dMHb^CKO) mice suggests that the dMHb constitutes a critical center for conveying reinforcement by exercise. However, WRA also represents a prominent output of the circadian system, and the possibility remains that the dMHb is a source of input to the master circadian pacemaker located in the suprachiasmatic nucleus (SCN) of the hypothalamus. To test this hypothesis, we assessed the integrity of the circadian system in dMHb^CKO

SUBMITTER: Hsu YA 

PROVIDER: S-EPMC5882496 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature