Cancer Stem Cell Phenotypes in ER⁺ Breast Cancer Models Are Promoted by PELP1/AIB1 Complexes.

ABSTRACT: Proline, glutamic acid, leucine-rich protein 1 (PELP1) is overexpressed in approximately 80% of invasive breast tumors. PELP1 dynamically shuttles between the nucleus and cytoplasm, but is primarily nuclear in normal breast tissue. However, altered localization of PELP1 to the cytoplasm is an oncogenic event that promotes breast cancer initiation and progression. Herein, interacting partners unique to cytoplasmic PELP1 and the mechanisms by which these interactions promote oncogenic PELP1 signaling were sought. AIB1 (amplified in breast cancer 1; also known as SRC-3 or NCOA3) was identified as a novel binding partner of cytoplasmic PELP1 in both estrogen receptor-positive (ER⁺) and ER-negative cell lines. Cytoplasmic PELP1 expression elevated basal phosphorylation levels (i.e.,

SUBMITTER: Truong TH 

PROVIDER: S-EPMC5882512 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature