Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner.
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ABSTRACT:
SUBMITTER: Jayaraman S
PROVIDER: S-EPMC5882536 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner.
Jayaraman Shobini S Gantz Donald L DL Haupt Christian C Fändrich Marcus M Gursky Olga O
Chemical communications (Cambridge, England) 20180401 28
Serum amyloid A action in immune response and deposition in inflammation-linked amyloidosis involve SAA-lipid interactions. We show that SAA sequesters neutral and anionic phospholipids and their hydrolytic products to form nanoparticles, suggesting a synergy with phospholipase A2. The lipid charge and shape affect SAA protection from proteolysis, aggregation and fibrillogenesis. ...[more]
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