Multigene Profiling of CTCs in mCRPC Identifies a Clinically Relevant Prognostic Signature.

ABSTRACT: The trend toward precision-based therapeutic approaches dictated by molecular alterations offers substantial promise for men with metastatic castration-resistant prostate cancer (mCRPC). However, current approaches for molecular characterization are primarily tissue based, necessitating serial biopsies to understand changes over time and are limited by the challenges inherent to extracting genomic material from predominantly bone metastases. Therefore, a circulating tumor cell (CTC)-based assay was developed to determine gene expression across a panel of clinically relevant and potentially actionable prostate cancer-related genes. CTCs were isolated from the whole blood of mCRPC patients (n = 41) and multiplex qPCR was performed to evaluate expression of prostate cancer-related targ

SUBMITTER: Singhal U 

PROVIDER: S-EPMC5882567 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature