Corticotropin releasing hormone can selectively stimulate glucose uptake in corticotropinoma via glucose transporter 1.

ABSTRACT:

Background

Pre-operative detection of corticotropin (ACTH) secreting microadenomas causing Cushing's disease (CD) improves surgical outcomes. Current best magnetic resonance imaging fails to detect up to 40% of these microadenomas. ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) is specific, but not sensitive in detecting corticotropinomas. Theoretically, secretagogue stimulation with corticotropin releasing hormone (CRH) could improve detection of adenomas with ¹⁸F-FDG PET. Previous attempts with simultaneous CRH stimulation have failed to demonstrate increased ¹⁸F-FDG uptake in corticotropinomas. We hypothesized that CRH stimulation leads to a delayed elevation in glucose uptake in corticotropinomas.

Methods

C

SUBMITTER: Lu J 

PROVIDER: S-EPMC5882598 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature