Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes.

ABSTRACT: Anteroposterior (AP) axis extension during gastrulation requires embryonic patterning and morphogenesis to be spatiotemporally coordinated, but the underlying genetic mechanisms remain poorly understood. Here we define a role for the conserved chromatin factor Gon4l, encoded by ugly duckling (udu), in coordinating tissue patterning and axis extension during zebrafish gastrulation through direct positive and negative regulation of gene expression. Although identified as a recessive enhancer of impaired axis extension in planar cell polarity (PCP) mutants, udu functions in a genetically independent, partially overlapping fashion with PCP signaling to regulate mediolateral cell polarity underlying axis extension in part by promoting notochord boundary formation. Gon4l limits expression of the

SUBMITTER: Williams MLK 

PROVIDER: S-EPMC5882663 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature