Ontology highlight
ABSTRACT:
SUBMITTER: Martin T
PROVIDER: S-EPMC5882848 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Martin Tesmine T Lou Yuan-Chao YC Chou Chun-Chi CC Wei Shu-Yi SY Sadotra Sushant S Cho Chao-Cheng CC Lin Meng-Hsuan MH Tai Jung-Hsiang JH Hsu Chun-Hua CH Chen Chinpan C
Scientific reports 20180403 1
Cyclophilin 1 (TvCyP1), a cyclophilin type peptidyl-prolyl isomerase present in the human parasite Trichomonas vaginalis, interacts with Myb1 and assists in its nuclear translocation. Myb1 regulates the expression of ap65-1 gene that encodes for a disease causing cytoadherence enzyme. Here, we determined the crystal structures of TvCyP1 and its complex with the minimum TvCyP1-binding sequence of Myb1 (Myb1<sup>104-111</sup>), where TvCyP1 formed a homodimer, unlike other single domain cyclophili ...[more]