Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection.

ABSTRACT: Monocytes are key cells in the immune dysregulation observed during human immunodeficiency virus (HIV) infection. The events that take place specifically in monocytes may contribute to the systemic immune dysfunction characterized by excessive immune activation in infected individuals, which directly correlates with pathogenesis and progression of the disease. Here, we investigated the immune dysfunction in monocytes from untreated and treated HIV + patients and associated these findings with epigenetic changes. Monocytes from HIV patients showed dysfunctional ability of phagocytosis and killing, and exhibited dysregulated cytokines and reactive oxygen species production after M. tuberculosis challenge in vitro. In addition, we showed that the expression of enzymes responsible for epigenet

SUBMITTER: Espindola MS 

PROVIDER: S-EPMC5882962 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature