Projected impact of HPV vaccination and primary HPV screening on cervical adenocarcinoma: Example from Australia.

ABSTRACT: Cytology-based cervical screening appears to have had a limited effect on the incidence of adenocarcinoma, however HPV vaccination and HPV-based screening will likely play a role in reducing future burden. Using Australia as an example, we estimated the future burden (2015-2040) of adenocarcinoma in the absence of other interventions; and the impact of HPV vaccination (introduced 2007) and HPV-based screening (commencing 2017). Future burden was estimated considering underlying trends in adenocarcinoma, using national data (1982-2010). The relative reduction in adenocarcinoma due to HPV vaccination and HPV-based screening was derived from observed clinical data. Adenocarcinoma incidence rates have been increasing since the early-mid 2000s (average annual increases from 3.0%(25-49 years) -8

SUBMITTER: Smith MA 

PROVIDER: S-EPMC5883242 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature