Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction.

ABSTRACT:

Background

Post-infarction cardiovascular remodeling and heart failure are the leading cause of myocardial infarction (MI)-driven death during the past decades. Experimental observations have involved intestinal microbiota in the susceptibility to MI in mice; however, in humans, identifying whether translocation of gut bacteria to systemic circulation contributes to cardiovascular events post-MI remains a major challenge.

Results

Here, we carried out a metagenomic analysis to characterize the systemic bacteria in a cohort of 49 healthy control individuals, 50 stable coronary heart disease (CHD) subjects, and 100 ST-segment elevation myocardial infarction (STEMI) patients. We report for the first time higher microbial richness and diversity in the systemic microbiome of STEMI

SUBMITTER: Zhou X 

PROVIDER: S-EPMC5883284 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature