Metabolic correlates of reserve and resilience in MCI due to Alzheimer's Disease (AD).

ABSTRACT: BACKGROUND:We explored the presence of both reserve and resilience in late-converter mild cognitive impairment due to Alzheimer's disease (MCI-AD) and in patients with slowly progressing amyloid-positive MCI by assessing the topography and extent of neurodegeneration with respect to both "aggressive" and typically progressing phenotypes and in the whole group of patients with MCI, grounding the stratification on education level. METHODS:We analyzed 94 patients with MCI-AD followed until conversion to dementia and 39 patients with MCI who had brain amyloidosis (AMY+ MCI), all with available baseline 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) results. Using a data-driven approach based on conversion time, patients with MCI-AD were divided into typical AD and late-converter

SUBMITTER: Bauckneht M 

PROVIDER: S-EPMC5883593 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature