Entropic Control of Receptor Recycling Using Engineered Ligands.

ABSTRACT: Receptor internalization by endocytosis regulates diverse cellular processes, from the rate of nutrient uptake to the timescale of essential signaling events. The established view is that internalization is tightly controlled by specific protein-binding interactions. However, recent work suggests that physical aspects of receptors influence the process in ways that cannot be explained by biochemistry alone. Specifically, work from several groups suggests that increasing the steric bulk of receptors may inhibit their uptake by multiple types of trafficking vesicles. How do biochemical and biophysical factors work together to control internalization? Here, we show that receptor uptake is well described by a thermodynamic trade-off between receptor-vesicle binding energy and the entropic cost

SUBMITTER: DeGroot ACM 

PROVIDER: S-EPMC5883623 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature