Response of Single Cells to Shock Waves and Numerically Optimized Waveforms for Cancer Therapy.

ABSTRACT: Shock waves are used clinically for breaking kidney stones and treating musculoskeletal indications. The mechanisms by which shock waves interact with tissue are still not well understood. Here, ultra-high-speed imaging was used to visualize the deformation of individual cells embedded in a tissue-mimicking phantom when subject to shock-wave exposure from a clinical source. Three kidney epithelial cell lines were considered to represent normal healthy (human renal epithelial), cancer (CAKI-2), and virus-transformed (HK-2) cells. The experimental results showed that during the compressive phase of the shock waves, there was a small (<2%) decrease in the projected cell area, but during the tensile phase, there was a relatively large (∼10%) increase in the projected cell area. The experimenta

SUBMITTER: Li D 

PROVIDER: S-EPMC5883951 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature