Neurological effects of proprotein convertase subtilisin/kexin type 9 inhibitors: direct comparisons.

ABSTRACT:

Aims

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors considerably alter the lipid profile. We sought to examine the rates of ischaemic stroke and neurocognitive deficits in patients treated with and without PCSK9 inhibitors.

Methods and results

Randomized controlled trials (RCTs) reporting rates of ischaemic stroke and neurocognitive deficits in patients using PCSK9 inhibitors were identified. Standard meta-analysis techniques were used to compare these outcomes among patients treated with and without PCSK9 inhibitors and the two US Food and Drug Administration-approved PCSK9 inhibitors, evolocumab and alirocumab. The results were presented in terms of risk ratio (RR) with 95% confidence intervals (CIs). Sixteen RCTs with 39 104 patients were included. Evolo

SUBMITTER: Bajaj NS 

PROVIDER: S-EPMC5884103 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature