Considerations for biomarker-targeted intervention strategies for tuberculosis disease prevention.

ABSTRACT: Current diagnostic tests for Mycobacterium tuberculosis (MTB) infection have low prognostic specificity for identifying individuals who will develop tuberculosis (TB) disease, making mass preventive therapy strategies targeting all MTB-infected individuals impractical in high-burden TB countries. Here we discuss general considerations for a risk-targeted test-and-treat strategy based on a highly specific transcriptomic biomarker that can identify individuals who are most likely to progress to active TB disease as well as individuals with TB disease who have not yet presented for medical care. Such risk-targeted strategies may offer a rapid, ethical and cost-effective path towards decreasing the burden of TB disease and interrupting transmission and would also be critical to achieving TB el

SUBMITTER: Fiore-Gartland A 

PROVIDER: S-EPMC5884308 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature