Effect of levosimendan on mortality in severe sepsis and septic shock: a meta-analysis of randomised trials.

ABSTRACT: OBJECTIVE:We aim to synthesise up-to-date randomised trials to investigate the effects of levosimendan on mortality and clinical outcomes in severe sepsis and septic shock. METHODS:A collection of databases including PubMed, EMBASE, Cochrane Central Register and Web of Science were searched updated to August 2017. Randomised trials were included when they pertain to the use of levosimendan in severe sepsis or septic shock compared with any category of inotropes, or as an adjunct to standard therapy with mortality reported. The primary outcome was mortality, and the secondary outcomes were clinical performances including serum lactate, cardiac function, vasopressor requirement and fluid infusion. RESULTS:A total of 10 studies with 1036 patients were included in this meta-analysis. The resul

SUBMITTER: Chang W 

PROVIDER: S-EPMC5884355 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature