In Vivo 6-([¹⁸F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity.

ABSTRACT:

Background

Histone deacetylases (HDACs) regulate gene expression by changing histone deacetylation status. Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA) and has excellent antitumor effects. Suberoylanilide hydroxamic acid (SAHA) is an HDAC inhibitor with neuroprotective effects against cisplatin-induced neurotoxicity.

Purpose

We investigated how cisplatin with and without SAHA pretreatment affects HDAC expression/activity in the brain by using 6-([¹⁸F]fluoroacetamido)-1-hexanoicanilide ([¹⁸F]FAHA) as a positron emission tomography (PET) imaging agent for HDAC IIa.

Materials and methods

[¹⁸F]FAHA and [¹⁸F]fluoro-2-deoxy-2-D-glucose ([¹⁸F]FDG) PET studies

SUBMITTER: Fukumitsu N 

PROVIDER: S-EPMC5884410 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature