Intra-operative characterisation of subthalamic oscillations in Parkinson's disease.

ABSTRACT:

Objective

This study aims to use the activities recorded directly from the deep brain stimulation (DBS) electrode to address the focality and distinct nature of the local field potential (LFP) activities of different frequency.

Methods

Pre-operative and intra-operative magnetic resonance imaging (MRI) were acquired from patients with Parkinson's disease (PD) who underwent DBS in the subthalamic nucleus and intra-operative LFP recording at rest and during cued movements. Images were reconstructed and 3-D visualized using Lead-DBS® toolbox to determine the coordinates of contact. The resting spectral power and movement-related power modulation of LFP oscillations were estimated.

Results

Both subthalamic LFP activity recorded at rest and its modulation by movement had fo

SUBMITTER: Geng X 

PROVIDER: S-EPMC5884428 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature