Population dynamics of engineered underdominance and killer-rescue gene drives in the control of disease vectors.

ABSTRACT: A number of different genetics-based vector control methods have been proposed. Two approaches currently under development in Aedes aegypti mosquitoes are the two-locus engineered underdominance and killer-rescue gene drive systems. Each of these is theoretically capable of increasing in frequency within a population, thus spreading associated desirable genetic traits. Thus they have gained attention for their potential to aid in the fight against various mosquito-vectored diseases. In the case of engineered underdominance, introduced transgenes are theoretically capable of persisting indefinitely (i.e. it is self-sustaining) whilst in the killer-rescue system the rescue component should initially increase in frequency (while the lethal component (killer) is common) before eventually decli

SUBMITTER: Edgington MP 

PROVIDER: S-EPMC5884568 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature