Role of Protein Kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis.

ABSTRACT: Sepsis is characterized by an intense systemic inflammatory response activating a cascade of proinflammatory events resulting in leukocyte dysregulation and host tissue damage. The lung is particularly susceptible to systemic inflammation, leading to acute lung injury. Key to inflammation-induced lung damage is the excessive migration of neutrophils across the vascular endothelium. The mechanisms which regulate neutrophil activation and migration in sepsis are not well defined but there is growing evidence that platelets are actively involved and play a key role in microvascular permeability and neutrophil-mediated organ damage. We previously identified PKC-delta (PKCδ) as a critical regulator of the inflammatory response in sepsis and demonstrated PKCδ inhibition was lung protective. Howe

SUBMITTER: Liverani E 

PROVIDER: S-EPMC5884571 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature