Unexpected widespread hypophosphatemia and bone disease associated with elemental formula use in infants and children.

ABSTRACT:

Objective

Hypophosphatemia occurs with inadequate dietary intake, malabsorption, increased renal excretion, or shifts between intracellular and extracellular compartments. We noticed the common finding of amino-acid based elemental formula [EF] use in an unexpected number of cases of idiopathic hypophosphatemia occurring in infants and children evaluated for skeletal disease. We aimed to fully characterize the clinical profiles in these cases.

Methods

A retrospective chart review of children with unexplained hypophosphatemia was performed as cases accumulated from various centres in North America and Ireland. Data were analyzed to explore any relationships between feeding and biochemical or clinical features, effects of treatment, and to identify a potential mechanism.

Re

SUBMITTER: Gonzalez Ballesteros LF 

PROVIDER: S-EPMC5884631 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature