Impact of adjuvant hormonotherapy on radiation-induced breast fibrosis according to the individual radiosensitivity: results of a multicenter prospective French trial.

ABSTRACT:

Background

To evaluate risk of severe breast fibrosis occurrence in patients treated by breast-conserving surgery, adjuvant radiotherapy and hormonotherapy (HT) according to individual radiosensitivity (RILA assay).

Results

HT^- and RILA^high were the two independent factors associated with improved breast-fibrosis free survival (BFFS). BFFS rate at 36 months was lower in patients with RILA^low and HT⁺ than in patients with RILA^high and HT^- (75.8% and 100%, respectively; p = 0.004, hazard ratio 5.84 [95% confidence interval (CI) 1.8-19.1]). Conversely, BFFS at 36 months was comparable in patients with RILA^high and HT⁺ and in patients with RILA^low and HT^- (89.8% a

SUBMITTER: Bourgier C 

PROVIDER: S-EPMC5884662 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature