Ontology highlight
ABSTRACT:
SUBMITTER: Pastuzyn ED
PROVIDER: S-EPMC5884693 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cell 20180101 1-2
The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain, mediates various forms of synaptic plasticity, and has been implicated in neurodevelopmental disorders. However, little is known about Arc's molecular function and evolutionary origins. Here, we show that Arc self-assembles into virus-like capsids that encapsulate RNA. Endogenous Arc protein is released from neurons in extracellular vesicles that mediate the transfer of Arc mRNA into new target cells, ...[more]