Establishing a Preclinical Multidisciplinary Board for Brain Tumors.

ABSTRACT: Purpose: Curing all children with brain tumors will require an understanding of how each subtype responds to conventional treatments and how best to combine existing and novel therapies. It is extremely challenging to acquire this knowledge in the clinic alone, especially among patients with rare tumors. Therefore, we developed a preclinical brain tumor platform to test combinations of conventional and novel therapies in a manner that closely recapitulates clinic trials.Experimental Design: A multidisciplinary team was established to design and conduct neurosurgical, fractionated radiotherapy and chemotherapy studies, alone or in combination, in accurate mouse models of supratentorial ependymoma (SEP) subtypes and choroid plexus carcinoma (CPC). Extensive drug repurposing scr

SUBMITTER: Nimmervoll BV 

PROVIDER: S-EPMC5884708 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature