Early life stress induces long-term changes in limbic areas of a teleost fish: the role of catecholamine systems in stress coping.

ABSTRACT: Early life stress (ELS) shapes the way individuals cope with future situations. Animals use cognitive flexibility to cope with their ever-changing environment and this is mainly processed in forebrain areas. We investigated the performance of juvenile gilthead seabream, previously subjected to an ELS regime. ELS fish showed overall higher brain catecholaminergic (CA) signalling and lower brain derived neurotrophic factor (bdnf) and higher cfos expression in region-specific areas. All fish showed a normal cortisol and serotonergic response to acute stress. Brain dopaminergic activity and the expression of the α2Α adrenergic receptor were overall higher in the fish homologue to the lateral septum (Vv), suggesting that the Vv is important in CA system regulation. Interestingly, ELS prevented

SUBMITTER: Vindas MA 

PROVIDER: S-EPMC5884775 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature