Rule-based modelling provides an extendable framework for comparing candidate mechanisms underpinning clathrin polymerisation.

ABSTRACT: Polymerisation of clathrin is a key process that underlies clathrin-mediated endocytosis. Clathrin-coated vesicles are responsible for cell internalization of external substances required for normal homeostasis and life -sustaining activity. There are several hypotheses describing formation of closed clathrin structures. According to one of the proposed mechanisms cage formation may start from a flat lattice buildup on the cellular membrane, which is later transformed into a curved structure. Creation of the curved surface requires rearrangement of the lattice, induced by additional molecular mechanisms. Different potential mechanisms require a modeling framework that can be easily modified to compare between them. We created an extendable rule-based model that describes polymerisation of

SUBMITTER: Sorokin A 

PROVIDER: S-EPMC5884807 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature