Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS).

ABSTRACT: Genome-wide association studies have identified numerous variants associated with lipid levels; yet, the majority are located in non-coding regions with unclear mechanisms. In the Insulin Resistance Atherosclerosis Family Study (IRASFS), heritability estimates suggest a strong genetic basis: low-density lipoprotein (LDL, h² = 0.50), high-density lipoprotein (HDL, h² = 0.57), total cholesterol (TC, h² = 0.53), and triglyceride (TG, h² = 0.42) levels. Exome sequencing of 1,205 Mexican Americans (90 pedigrees) from the IRASFS identified 548,889 variants and association and linkage analyses with lipid levels were performed. One genome-wide significant signal was detected in APOA5 with TG (rs651821, P_TG = 3.67 × 10^-10, LOD_TG

SUBMITTER: Gao C 

PROVIDER: S-EPMC5884862 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature