Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression.

ABSTRACT: Mouse models and genetically engineered mouse models (GEMM) are essential experimental tools for the understanding molecular mechanisms within complex biological systems. GEMM are especially useful for inferencing phenocopy information to genetic human diseases such as breast cancer. Human breast cancer modeling in mice most commonly employs mammary epithelial-specific promoters to investigate gene function(s) and, in particular, putative oncogenes. Models are specifically useful in the mammary epithelial cell in the context of the complete mammary gland environment. Gene targeted knockout mice including conditional targeting to specific mammary cells can reveal developmental defects in mammary organogenesis and demonstrate the importance of putative tumor suppressor genes. Some of these m

SUBMITTER: Mori H 

PROVIDER: S-EPMC5884881 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature