Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer.

ABSTRACT:

Importance

Treatment of locally advanced rectal (LARC) cancer involves chemoradiation, surgery, and chemotherapy. The concept of total neoadjuvant therapy (TNT), in which chemoradiation and chemotherapy are administered prior to surgery, has been developed to optimize delivery of effective systemic therapy aimed at micrometastases.

Objective

To compare the traditional approach of preoperative chemoradiation (chemoRT) followed by postoperative adjuvant chemotherapy with the more recent TNT approach for LARC.

Design, setting, and participants

A retrospective cohort analysis using Memorial Sloan Kettering Cancer Center (MSK) records from 2009 to 2015 was carried out. A total of 811 patients who presented with LARC (T3/4 or node-positive) were identified.

Exposures

SUBMITTER: Cercek A 

PROVIDER: S-EPMC5885165 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature