Effect of General Anesthesia and Conscious Sedation During Endovascular Therapy on Infarct Growth and Clinical Outcomes in Acute Ischemic Stroke: A Randomized Clinical Trial.

ABSTRACT:

Importance

Endovascular therapy (EVT) is the standard of care for select patients who had a stroke caused by a large vessel occlusion in the anterior circulation, but there is uncertainty regarding the optimal anesthetic approach during EVT. Observational studies suggest that general anesthesia (GA) is associated with worse outcomes compared with conscious sedation (CS).

Objective

To examine the effect of type of anesthesia during EVT on infarct growth and clinical outcome.

Design, setting, and participants

The General or Local Anesthesia in Intra Arterial Therapy (GOLIATH) trial was a single-center prospective, randomized, open-label, blinded end-point evaluation that enrolled patients from March 12, 2015, to February 2, 2017. Although the trial screened 1501 patient

SUBMITTER: Simonsen CZ 

PROVIDER: S-EPMC5885172 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature