Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy: A Randomized Clinical Trial.

ABSTRACT:

Importance

Management of painful diabetic peripheral neuropathy remains challenging. Most therapies provide symptomatic relief with varying degrees of efficacy. Tocotrienols have modulatory effects on the neuropathy pathway and may reduce neuropathic symptoms with their antioxidative and anti-inflammatory activities.

Objective

To evaluate the efficacy of oral mixed tocotrienols for patients with diabetic peripheral neuropathy.

Design, setting, and participants

The Vitamin E in Neuroprotection Study (VENUS) was a parallel, double-blind, placebo-controlled trial that recruited participants from January 30, 2011, to December 7, 2014, with 12 months of follow-up. This trial screened 14 289 patients with diabetes from 6 health clinics and ambulatory care units from 5 publi

SUBMITTER: Vitamin E in Neuroprotection Study (VENUS) Investigators 

PROVIDER: S-EPMC5885181 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature