Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab.

ABSTRACT:

Importance

Powassan virus is a rare but increasingly recognized cause of severe neurological disease.

Objective

To highlight the diagnostic challenges and neuropathological findings in a fatal case of Powassan encephalitis caused by deer tick virus (lineage II) in a patient with follicular lymphoma receiving rituximab, with nonspecific anti-GAD65 antibodies, who was initially seen with fever and orchiepididymitis.

Design, setting, and participants

Comparison of clinical, radiological, histological, and laboratory findings, including immunohistochemistry, real-time polymerase chain reaction, antibody detection, and unbiased sequencing assays, in a single case report (first seen in December 2016) at an academic medical center.

Exposure

Infection with Powassan vir

SUBMITTER: Solomon IH 

PROVIDER: S-EPMC5885183 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature