Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease.

ABSTRACT:

Importance

Circadian rhythm disturbances occur in symptomatic Alzheimer disease (AD) and have been hypothesized to contribute to disease pathogenesis. However, it is unknown whether circadian changes occur during the presymptomatic phase of the disease.

Objective

To examine the associations between circadian function, aging, and preclinical AD pathology in cognitively normal adults.

Design, setting, and participants

This cross-sectional study was conducted using community volunteers from the Knight Alzheimer's Disease Research Center at Washington University in St Louis. Cognitively normal participants (n = 205) underwent 7 to 14 days of actigraphy in their home environment between 2010 and 2012, in addition to clinical assessment, amyloid imaging with Pittsburgh Comp

SUBMITTER: Musiek ES 

PROVIDER: S-EPMC5885197 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature