Modification of the Associations Between Duration of Oral Contraceptive Use and Ovarian, Endometrial, Breast, and Colorectal Cancers.

ABSTRACT:

Importance

Although oral contraceptive (OC) use is common, the influence of OC use on carcinogenesis is not fully understood. A recent Agency for Healthcare Research and Quality report identified a need to understand the consistency of OC use and cancer associations across subpopulations, including smokers and obese women.

Objective

To determine whether associations between duration of OC use and risk of specific cancers were modified by lifestyle characteristics.

Design, setting, and participants

The prospective NIH-AARP Diet and Health Study (enrolled 1995-1996, followed until 2011), with population-based recruitment of AARP members in 6 states and 2 metropolitan areas. All analyses included at least 100 000 women who reported OC use at enrollment. We identified 124

SUBMITTER: Michels KA 

PROVIDER: S-EPMC5885214 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature