Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease.

ABSTRACT:

Importance

Alzheimer disease (AD) develops during several decades. Presymptomatic individuals might be the best candidates for clinical trials, but their identification is challenging because they have no symptoms.

Objective

To assess whether a sporadic parental estimated years to symptom onset calculation could be used to identify information about amyloid-β (Aβ) levels in asymptomatic individuals with a parental history of AD dementia.

Design, setting, and participants

This cohort study analyzed Aβ1-42 in cerebrospinal fluid (CSF) specimens from 101 cognitively normal individuals who had a lumbar puncture as part of the Presymptomatic Evaluation of Novel or Experimental Treatments for Alzheimer Disease (PREVENT-AD) cohort from September 1, 2011, through November 30,

SUBMITTER: Villeneuve S 

PROVIDER: S-EPMC5885216 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature