Genetic variation associated with increased insecticide resistance in the malaria mosquito, Anopheles coluzzii.

ABSTRACT:

Background

Malaria mortality rates in sub-Saharan Africa have declined significantly in recent years as a result of increased insecticide-treated bed net (ITN) usage. A major challenge to further progress is the emergence and spread of insecticide resistance alleles in the Anopheles mosquito vectors, like An. coluzzii. A non-synonymous mutation in the para voltage-gated sodium channel gene reduces pyrethroid-binding affinity, resulting in knockdown resistance (kdr). Metabolic mechanisms of insecticide resistance involving detoxification genes like cytochrome P450 genes, carboxylesterases, and glutathione S-transferases are also important. As some gene activity is tissue-specific and/or environmentally induced, gene regulatory variation may be overlooked when comparing expression fr

SUBMITTER: Main BJ 

PROVIDER: S-EPMC5885317 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature