Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma.

ABSTRACT:

Background

Lymph node metastasis (LNM) is a major determinant of prognosis and treatment planning of oral squamous cell carcinoma (OSCC). Cysteine cathepsins constitute a family of proteolytic enzymes with known role in the degradation of the extracellular matrix. Involvement in pathological processes, such as inflammation and cancer progression, has been proved. The aim of the study was to discover the clinicopathological and prognostic implications of cathepsin K (CTSK) expression in oral squamous cell carcinoma.

Methods

Eighty-three patients with primary OSCC, treated surgically between 1996 and 2000, were included. Gene expression data were acquired from a previously reported study. Human papilloma virus (HPV) status was previously determined by an algorithm for HPV-16.

SUBMITTER: Leusink FK 

PROVIDER: S-EPMC5885370 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature