Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination.

ABSTRACT: BACKGROUND:One of today's greatest hurdles for cancer immunotherapy is the absence of information regarding which tumor antigens are already recognized by patients receiving immunotherapies, and whether those therapies then boost or generate an immune response against tumor proteins. For CD8+ T cells in particular, patient-specific immune recognition and responses at the level of individual tumor antigens are rarely characterized. Because of this, some immunologists have turned to serum antibodies as an alternative measure of antigen-specific anti-tumor immunity. In this work, we sought to simultaneously interrogate serum IgG and CD8+ T cell recognition of individual tumor antigens to determine whether antigen-specific serum IgG antibodies provide a window into the behavior of antigen-spec

SUBMITTER: Hulett TW 

PROVIDER: S-EPMC5885379 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature