Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer.

ABSTRACT:

Background

Ovarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late detection, an advanced disease state, and the need for chemotherapy. Ovarian cancer is frequently sensitive to chemotherapy at diagnosis but rapid development of drug resistance leads to disease progression and ultimately death in the majority of patients.

Results

We have generated paclitaxel resistant ovarian cell lines from their corresponding native cell lines to determine driver mechanisms of drug resistance using gene expression arrays. These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC₅₀ for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2)

SUBMITTER: Chong T 

PROVIDER: S-EPMC5885411 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature