DNA Methylation in Osteoarthritis: Current Status and Therapeutic Implications.

ABSTRACT:

Background

Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors are strongly associated with its development; however, recently it has been observed that epigenetic modifications are also involved in the pathogenesis of OA. DNA methylation is related to gene silencing, and several studies have investigated its role in the loci of different pathways or molecules associated to OA.

Objective

This review is focused on the current status of DNA methylation studies related to OA pathogenesis.

Method

A review of the literature was conducted on searching in PUBMED for original papers on DNA methylation in OA.

Conclusion

The DNA methylation research of loci related to OA pathogenesis has shown a correlation between methylation a

SUBMITTER: Miranda-Duarte A 

PROVIDER: S-EPMC5885469 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature