Site-selective ¹⁸F fluorination of unactivated C-H bonds mediated by a manganese porphyrin.

ABSTRACT: The first direct C-H ¹⁸F fluorination reaction of unactivated aliphatic sites using no-carrier-added [¹⁸F]fluoride is reported. Under the influence of a manganese porphyrin/iodosylbenzene system, a variety of unactivated aliphatic C-H bonds can be selectively converted to C-¹⁸F bonds. The mild conditions, broad substrate scope and generally inaccessible regiochemistry make this radio-fluorination a powerful alternate to established nucleophilic substitution for the preparation of ¹⁸F labeled radio tracers.

SUBMITTER: Liu W 

PROVIDER: S-EPMC5885592 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature