Neuroanatomic Differences Associated With Stress Susceptibility and Resilience.

ABSTRACT:

Background

We examined the neurobiological mechanisms underlying stress susceptibility using structural magnetic resonance imaging and diffusion tensor imaging to determine neuroanatomic differences between stress-susceptible and resilient mice. We also examined synchronized anatomic differences between brain regions to gain insight into the plasticity of neural networks underlying stress susceptibility.

Methods

C57BL/6 mice underwent 10 days of social defeat stress and were subsequently tested for social avoidance. For magnetic resonance imaging, brains of stressed (susceptible, n = 11; resilient, n = 8) and control (n = 12) mice were imaged ex vivo at 56 µm resolution using a T2-weighted sequence. We tested for behavior-structure correlations by regressing social avoidance

SUBMITTER: Anacker C 

PROVIDER: S-EPMC5885767 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature