Association of Oral Microbiome With Risk for Incident Head and Neck Squamous Cell Cancer.

ABSTRACT:

Importance

Case-control studies show a possible relationship between oral bacteria and head and neck squamous cell cancer (HNSCC). Prospective studies are needed to examine the temporal relationship between oral microbiome and subsequent risk of HNSCC.

Objective

To prospectively examine associations between the oral microbiome and incident HNSCC.

Design, setting, and participants

This nested case-control study was carried out in 2 prospective cohort studies: the American Cancer Society Cancer Prevention Study II Nutrition Cohort (CPS-II) and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Among 122 004 participants, 129 incident patient cases of HNSCC were identified during an average 3.9 years of follow-up. Two controls per patient case (n 

SUBMITTER: Hayes RB 

PROVIDER: S-EPMC5885828 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature