Association of Polygenic Risk Score With Cognitive Decline and Motor Progression in Parkinson Disease.

ABSTRACT:

Importance

Genetic factors have a well-known influence on Parkinson disease (PD) susceptibility. The largest genome-wide association study (GWAS) identified 26 independent single-nucleotide polymorphisms (SNPs) associated with PD risk. Among patients, the course and severity of symptom progression is variable, and little is known about the potential association of genetic factors with phenotypic variance.

Objective

To assess whether GWAS-identified PD risk SNPs also have a cumulative association with the progression of cognitive and motor symptoms in patients with PD.

Design, setting, and participants

This longitudinal population-based cohort study of 285 patients of European ancestry with incident PD genotyped 23 GWAS SNPs. One hundred ninety-nine patients were follo

SUBMITTER: Paul KC 

PROVIDER: S-EPMC5885856 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature