Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis.

ABSTRACT:

Importance

Late-onset Alzheimer disease (AD) is highly heritable. Genome-wide association studies have identified more than 20 AD risk genes. The precise mechanism through which many of these genes are associated with AD remains unknown.

Objective

To investigate the association of the top 20 AD risk variants with brain amyloidosis.

Design, setting, and participants

This study analyzed the genetic and florbetapir F 18 data from 322 cognitively normal control individuals, 496 individuals with mild cognitive impairment, and 159 individuals with AD dementia who had genome-wide association studies and 18F-florbetapir positron emission tomographic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), a prospective, observational, multisite tertiary center clinic

SUBMITTER: Apostolova LG 

PROVIDER: S-EPMC5885860 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature